administration of agents to avoid additional secondary toxicity by inflammation or superinfection during the treatment cycle (supportive care) and 3. administration of cyto- or radioprotective agents prior to irradiation, 2. Different approaches may be chosen to protect healthy tissues from the effects of ionizing radiation: 1. The evaluation was focused on therapeutic principles but not on special drugs. A database research (Medline, Cancerlit, DIMDI, etc.) was performed in order to obtain pharmacological approaches to decrease the acute radiation morbidity. The acute radiation morbidity may be a serious problem for the patient and may be decreased by pharmacological approaches. Pharmacological management of acute radiation morbidity. No commercial use is permitted unless otherwise expressly granted. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. This approach opens the door for considerably broader use of perinatal morbidity scoring tools as a primary outcome in applied population and clinical maternal-infant health research studies. Applying the proposed Poisson regression to the case study showed a protective risk ratio for adverse outcome following closures as compared with the original analysis, where no difference was found. The approach is illustrated using an existing maternal-neonatal scoring tool, the Adverse Outcome Index, to evaluate the safety of labour and delivery before and after the closure of obstetrical services in small rural communities. We outline these challenges and describe a solution, based on Poisson regression, that allows differences in perinatal morbidity scores to be formally evaluated. However, they have proved difficult to implement as a primary outcome in applied research studies because of challenges in testing if the scores are significantly different between two or more study groups. Perinatal morbidity scores are appealing for maternal-infant health researchers because they provide a way to capture a broad range of adverse events to mother and newborn while recognising that some events are considered more serious than others. Perinatal morbidity scores are tools that score or weight different adverse events according to their relative severity.
Hutcheon, Jennifer A Bodnar, Lisa M Platt, Robert W Using perinatal morbidity scoring tools as a primary study outcome.
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